﻿                         SEQUENCE LISTING

<110>  武汉大学
 
<120>  Nav1.9的靶点多肽、与其结合的抗体及抗体片段和相关药物组合物

<130>  WH1954-18P421861

<160>  13    

<170>  PatentIn version 3.3

<210>  1
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  与抗体特异性结合的多肽

<400>  1

Leu Asn Ser Phe Ser Asn Glu Glu Arg Asn Gly Asn Leu Glu 
1               5                   10                  


<210>  2
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  重链可变区

<400>  2

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn Pro Arg Asn Gly Arg Ile Asn Gln Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Ala Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Gly Gly Gly Ser Ser Ala Glu Gly Gly Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  3
<211>  131
<212>  PRT
<213>  Artificial

<220>
<223>  轻链可变区

<400>  3

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Leu Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Gln 
    130     


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1

<400>  4

Ser Tyr Trp Met His 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2

<400>  5

Glu Ile Asn Pro Arg Asn Gly Arg Ile Asn Gln Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  6
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3

<400>  6

Gly Gly Gly Ser Ser Ala Glu Gly Gly Tyr 
1               5                   10  


<210>  7
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1

<400>  7

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL2

<400>  8

Lys Val Phe Asn Arg Leu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3

<400>  9

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  10
<211>  414
<212>  DNA
<213>  Artificial

<220>
<223>  重链可变区的DNA序列

<400>  10
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgt ccactcccag     60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagctgtcc    120

tgcaaggctt ctggctacac cttcaccagc tactggatgc actgggtgaa gcagaggcct    180

ggacaaggcc ttgagtggat tggagagatt aatcctagga acggtcgtat taaccagaat    240

gagaagttca agagcaaggc cacactgact gtagccaaat cctccagcac ggcctacatg    300

caactcagca gcctgacatc tgaggactct gcggtctatt actgttcaag agggggcggt    360

agtagcgcgg aggggggcta ctggggccaa ggcaccactc tcacagtctc ctca          414


<210>  11
<211>  393
<212>  DNA
<213>  Artificial

<220>
<223>  轻链可变区的DNA序列

<400>  11
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat     60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc    120

tcttgcagat ctagtcagag cattgtacat agtaatggaa acacctattt agattggtac    180

ctgcagaaac caggccagtc tccaaagctc ctgatataca aagttttcaa ccgactttct    240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc    300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttcctctc    360

acgttcggtg ccgggaccaa gctggagctg caa                                 393


<210>  12
<211>  414
<212>  RNA
<213>  Artificial

<220>
<223>  重链可变区的RNA序列

<400>  12
augggaugga gcuauaucau ccucuuuuug guagcaacag cuacagaugu ccacucccag     60

guccaacugc agcagccugg ggcugaacug gugaagccug gggcuucagu gaagcugucc    120

ugcaaggcuu cuggcuacac cuucaccagc uacuggaugc acugggugaa gcagaggccu    180

ggacaaggcc uugaguggau uggagagauu aauccuagga acggucguau uaaccagaau    240

gagaaguuca agagcaaggc cacacugacu guagccaaau ccuccagcac ggccuacaug    300

caacucagca gccugacauc ugaggacucu gcggucuauu acuguucaag agggggcggu    360

aguagcgcgg aggggggcua cuggggccaa ggcaccacuc ucacagucuc cuca          414


<210>  13
<211>  393
<212>  RNA
<213>  Artificial

<220>
<223>  轻链可变区的RNA序列

<400>  13
augaaguugc cuguuaggcu guuggugcug auguucugga uuccugcuuc cagcagugau     60

guuuugauga cccaaacucc acucucccug ccugucaguc uuggagauca agccuccauc    120

ucuugcagau cuagucagag cauuguacau aguaauggaa acaccuauuu agauugguac    180

cugcagaaac caggccaguc uccaaagcuc cugauauaca aaguuuucaa ccgacuuucu    240

ggggucccag acagguucag uggcagugga ucagggacag auuucacacu caagaucagc    300

agaguggagg cugaggaucu gggaguuuau uacugcuuuc aagguucaca uguuccucuc    360

acguucggug ccgggaccaa gcuggagcug caa                                 393


